Diagnosis and localisation of occult gastro-intestinal bleeding Activity injected for blood pool scintigraphy (740 - 925 MBq)
Determination of plasma volume and total blood volume
Examination of albumin turnover.
The suggested activity range for intravenous use to a patient of average weight (70 kg) is:
Myocardial perfusion scintigraphy: 400-900 MBq
Assessment of global ventricular function: 600-800 MBq injected as a bolus.
For diagnosis of ischaemic heart disease two injections (stress and rest) are required in order to differentiate transiently from persistently reduced myocardial uptake.
The recommended activity range for diagnosis of ischaemic heart disease according to the European procedural guideline is:
Two-day protocol: 600–900 MBq/study
One-day protocol: 400–500 MBq
for the first injection, three times more for the second injection. Not more than a total of 2000 MBq should be administered for a one-day protocol and 1800 MBq for a two-day-protocol. For a one day protocol, the two injections (stress and rest) should be done at least two hours apart but may be performed in either order.
After the stress injection, exercise should be encouraged for an additional one minute (if possible).
For diagnosis of myocardial infarction one injection at rest may be sufficient.
The injection of activities greater than local DRLs (Diagnostic Reference Levels) should be justified.
Scinti-mammography for the detection of suspected breast cancer: 750-1000 MBq injected as a bolus in the arm opposite to the lesion.
Localisation of hyperfunctioning parathyroid tissue:
200–1000 MBq injected as a bolus (the activity used should in every case be as low as reasonably practical). The typical activity is 740 MBq.
Children and adolescents:
For pediatric use, please refer to the full SPC.
Myocardial scintigraphy in the evaluation of coronary perfusion and cellular viability.
Scintigraphy of the muscles.
Thallium avid tumour visualisation in different organs, especially for the brain tumours and thyroid tumours and metastases.
Treatment of rheumatoid mono or oligo-arthritis involving one or few of the small joints of the hands and feet following failure of intra-articular corticosteroid therapy or when the latter is contra-indicated
Treatment of rheumatoid mono or oligo arthritis involving mediumsized joints (shoulders, elbows, wrists, ankles, hips) and particularly rheumatoid polyarthritis
Treatment of haemophilic or chronic arthropathy associated with articular chondrocalcinosis.
Therapeutic irradiation of synovial hypertrophy of knee joints mainly for mono- or oligo-articular arthritis of chronic inflammatory rheumatism particularly rheumatoid polyarthritis
In conjunction with other appropriate imaging modalities determination of the location of inflammation/infection peripheral bone in adults with suspected osteomyelitis (400-800 MBq). Should not be used for the diagnosis of diabetic foot infection